Gene
gfm2
- ID
- ZDB-GENE-060201-3
- Name
- GTP dependent ribosome recycling factor mitochondrial 2
- Symbol
- gfm2 Nomenclature History
- Previous Names
-
- si:dkey-35i22.3 (1)
- zgc:153835
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 39 | Alliance | Combined oxidative phosphorylation deficiency 39 | 618397 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000640 | Elongation factor EFG, domain V-like |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR005225 | Small GTP-binding domain |
| Domain | IPR005517 | Translation elongation factor EFG/EF2, domain IV |
| Domain | IPR009022 | Elongation factor G, domain III |
| Domain | IPR035649 | EFG, domain V |
| Domain | IPR041095 | Elongation Factor G, domain II |
| Family | IPR030851 | Ribosome-releasing factor 2, mitochondrial |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR035647 | EF-G domain III/V-like |
Domain Details Per Protein
| Protein | Length | EF-G domain III/V-like | EFG, domain V | Elongation factor EFG, domain V-like | Elongation Factor G, domain II | Elongation factor G, domain III | P-loop containing nucleoside triphosphate hydrolase | Ribosomal protein uS5 domain 2-type superfamily | Ribosome-releasing factor 2, mitochondrial | Small GTP-binding domain | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Translational (tr)-type GTP-binding domain | Translation elongation factor EFG/EF2, domain IV | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AZN0
|
533 | |||||||||||||||
|
UniProtKB:A0JMI9
|
762 |
Interactions and Pathways
No data available
Plasmids
No data available